SINDROMUL SJOGREN

 

Sindromul Sjogren 1Sindromul  Sjögren este o boala autoimuna caracterizata de uscaciunea cronica a ochilor si a gurii, asociata de asemenea, cu uscaciune in zona organelor genitale externe, urechii, nasului si gatului. Pot fi scazute, de asemenea, secretiile in tractul gastro-intestinal.
Simptome sunt cauzate de infiltrarea celulelor sistemului imunitar, de obicei, limfocite B si T, in glandele responsabile de secretia de lichide. Limfocitele infiltrate sunt capabile sa produca atat citokine Th1 si cat si Th2 , dar echilibrul dintre ele se schimba in favoarea Th1 la pacientii cu concentratii de infiltrare mari.

Boala poate sa apara singura (s.Sjogren primar) sau in combinatie cu alte boli autoimune (s. Sjögren secundar -la cca 10-30% din pacienti cu boli autoimune ale tesutului conjunctiv). Ea poate fi asociata cu artrita reumatoida, lupusul eritematos sistemic, sclerodermia, si alte boli ale tesutului conjunctiv (Talal N 1987) sau poate fi asociata cu boli autoimune ale glandelor timus si tiroida (MN Lazar et al 2005).

Sindromul Sjogren afecteaza 1 persoana din 500 si este a doua boala reumatologica ca incidenta dupa SLE . Aproximativ 90 la suta dintre victime sunt femei (cca 0,5% din total femei) cu o varsta medie de 50 de ani, desi poate afecta orice grup de varsta, chiar si copii (Talal N 1987).

 

Desi boala Sjogren nu afecteaza durata de viata a unui pacient, ea afecteaza semnificativ calitatea vietii:

 

(1) Uscaciunea oculara – simptome:  reactii inflamatorii (Badouin C 2001), lasand un sentiment de nisip in ochi si de intoleranta la lumina. Suprafata inasprita a ochiului cauzata de uscaciune face ca lumina sa se imprastie, rezultand vederea incetosata. Sindromul de ochi uscat face, de asemenea, ochii mai sensibili la iritanti si mai predispusi la infectii, ce pot duce la ulceratii corneene daca sunt lasate netratate. Dermatita pleoapelor poate fi o alta manifestare a sindromului Sjögren primar.

Uscaciunea oculara poate duce la ulcere ale corneei si keratoconjunctivita

 

(2) Uscaciunea orala – simptome:  saliva redusa -> o gura uscata, lipicios, si dificultati in masticatie si inghitire.  Cantitatea a scazut de saliva face cavitatea bucala mai acid, iar pH-ul redus, impreuna cu reducerea numarului de enzime prezente in mod normal, antibacteriene saliva umana, face dinte carii o problema semnificativa. Cariilor dentare este considerat un marker potential pentru boala (Lynge Pedersen AM et al 2005). Gura uscata poate afecta, de asemenea, procesul de vorbire, gustul, si toleranta fata de proteze dentare.

 

(3) Alte simptome asociate sindromului Sjogren includ urmatoarele:

  • uscaciune si congestie  nazala, sangerari nazale,  afectarea  gustului  si mirosului
  • uscaciunea  in trompa lui  Eustachio à  infundarea urechilor si scaderea auzului
  • senzatie de mancarime, piele uscata
  • uscaciune vaginala

 

Afectarile extraglandulare pot fi:

(1) respiratorii: bronsita cronica, pneumonita interstitiala;

(2) gastrointestinale: reflux esofagian, gastrita atropica, afectare hepatica, pancreatita etc à malabsorbtie

(3) piele si membrane mucoase: purpura, vasculita, sindrom Raynaud

(4) neurologice : depresie, tulburari de memorie, concentrare redusa, neuropatie centrala (in special trigemen) sau periferica, afectarea nervilor cranieni in debutul paraliziei faciale (Rousso E, et al 2005).

(5) musculoscheletale: mialgii (20-30%), artralgii (60-70%), oboseala (60%)

(6) hematologice: neutropenie, anemie, trombocitopenie

(7) renale:  nefrita interstitiala, glomerulonefrita, crio-globulinemie mixta

(8) limfatice: limfadenopatie (20%), pseudolimfom (10%) si limfom Hodgkins la cap si gat

(9) cancerul glandelor salivare

 

Sindromul Sjogren 2Deoarece  progreseaza lent, sindromul Sjögren este frecvent diagnosticat gresit si netratat (Derk CT et al 2004). Simptomele de sindromul Sjögren primar – uscaciune, oboseala, dureri de  cap si de gat, raguseala sau pierderea auzului, poate aparea, de asemenea, ca un rezultat al utilizarii medicamentelor, starilor de anxietate si depresie, sau in procesul normal de imbatranire (Mahoney EJ 2003; Mariette X 2002). Intr-un studiu chinez, timpul mediu dintre debutul simptomelor si stabilirea diagnosticului
a fost de 7,8 ani, indicand faptul ca in cele mai multe cazuri boala fost diagnosticata eronat sau a fost neglijata (NZ Zhang 1993).

 

*

Medicina alopata  ofera suport pentru diminuarea simptomelor si prevenirea complicatiilor.

  • Antiinflamatoare nesteroidiene contra durerii si inflamatiei (efecte secundare: indigestie si sangerari digestive);
    Corticosteroizi: reduc inflamatia si degenerarea articulatiilor;
  • Picaturi pentru stimularea producerii de saliva; (a se evita administrarea la cardiaci, astamatici si la cei cu glaucom)
  • Ciclosporina: imbunatateste functia glandelor lacrimale;
  • Imunosupresoare: in caz de complicatii pulmonare, renale, vasculare etc

 

SUPORT INFO-ENERGETIC IN SINDROMUL SJOGREN

Centrul EUVITA ofera  protocolul Sjogren-Ease care urmareste sa echilibreze sistemul imunitar prin modularea neinvaziva a activitatii celulelor T, care sa tina seama de toate interactiunile dintre sistemul imunitar, endocrin si nervos.

Protocolul  Sjogren-Ease debuteaza cu explorarea energetica functionala care evalueaza cauzele posibile (mimetism molecular, celule T imature, aptoza deficitara,  probleme gastrointestinale si alergii/intolerante alimentare), comorbiditati prezente, riscuri posibile. Sunt  identificate profilul imunologic, hormonal, modul de raspuns al organismului, ecotoxinele prezente, stresul oxidativ, deficit / exces de nutrienti (ex: Vit.A, lipide), influenta fumat / aer conditionat / medicamente (ex: antihistaminice), imbatranirea prematura etc

 

Terapia Sjogren-Ease urmareste echilibrarea balantei intre Th1 si Th2 pentru intrarea in remisie a bolii: aparatul SCIO poseda o functie speciala in acest sens – Auto Aggressive Immune Disorder. De asemenea se urmareste detoxifierea si echilibrarea neurohormonala prin eliminarea stresorilor specifici, drenarea sistemului limfatic, corectia automata a nivelului enzimelor, reducerea stresului oxidativ, reducerea inflamatiei, controlul infectiilor  bacteriene, fungice sau virale (inclusiv /mai ales prin metode electrice: ZAP therapy / terapie Rife) etc.

 

Terapia Sjogren-Ease este unica deoarece ofera suport  simultan pentru posibilele boli autoimune conexe  (lupus, tiroidita autoimuna, artrita reumatoida) sau sindroame poliglandulare autoimune (afectare simultana glande endocrine).

Rezultatele apar dupa 4-6 luni, dupa parcurgerea primelor etape ale terapiei. Remisia bolii poate sa apara dupa 12-18 luni, dar ea nu inseamna incetarea completa a terapiei, ci doar inlocuirea ei cu o terapia de intretinere, care trebuie mentinuta pentru controlul infectiilor, detoxifiere periodica (2-3 ori/an), echilibru neuro-imuno-endocrin si energetico-metabolic etc

 

Protocolul Sjogren-Ease reprezinta o solutie complexa si completa, eficienta si neinvaziva, pentru reglarea sistemului imunitar si remisia / incetinirea substantiala a evolutiei sindromului Sjogren si a afectiunilor conexe.

 

 

 

REFERINTE:

  • The influence of electroacupuncture on salivary flow rates“  – I. Dawidson, M.Blom, T. Lundeberg, B. Angmar-Mansson – Karolinks Institutet, Stockholm;   Journal of Oral Rehabilitation 1997 24; 204-208
  • Effects on local blood flux of acupuncture stimulation used to treat xerostomia in patients suffering from Sjögren’s syndrome” -   Blom M, Lundeberg T, Dawidson I, Angmar-Månsson B – J Oral Rehabil. 1993 Sep;20(5):541-8.
  • “Results of applying bioresonance and multiresonance therapies in ophthalmology”,   Tarakanovski A.V.. (Helmgolz’s Moscow SRI of eye diseases, Moscow, Russia);   Proceedings of the VI International Conference “Theoretical and clinical aspects of application of bioresonance and multiresonance therapy”
  • Activation by True vs Placebo Acupuncture for Xerostomia” -  Deng G & al – BMC Comple Alt Med 2008
  • Pilot Study of Impedance-controlled Microcurrent Therapy for Managing Xerostomia …”   – J.P. Shafer, A.J. Lennox, M.A. Hatcher, J.K. Beil,  S.J. Funder – Int J Radiat Oncol Biol Phys. 2002 Sep 1;54(1):23-34.
  • Neuroelectric therapy eliminates xerostomia …”   -   Boswell, NS  – Medical Electronics, 115:105-107, February, 1989

 

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